management validations toxicology environmental monitoring biocompatibility hatch quality management system controlled area differential phase calibration preventive action operational excellence accent reduction nanoparticles track geometry nitrate reduction writing nanobiotechnology research validation quality assurance quality control pharmacology contamination drug discovery draft medical device assembly good documentation practices sampling mycology management system stamping microbiology cytotoxicity creativity corrective and preventive action (capa) good laboratory practice (glp) reconciliation cleanliness quality management change control